Structure of PDB 6u2g Chain B

Receptor sequence
>6u2gB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
EIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKN
EVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEM
IKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN
INNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFP
QILASIELLARSLP
3D structure
PDB6u2g Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization.
ChainB
Resolution2.886 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D126 K128 N130 N131 D144 S158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N581 D594 N131 D144
BS02 ACP B I463 G464 G466 S467 V471 W531 C532 D576 K578 N580 N581 F583 D594 I13 G14 G16 S17 V21 W81 C82 D126 K128 N130 N131 F133 D144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6u2g, PDBe:6u2g, PDBj:6u2g
PDBsum6u2g
PubMed31988522
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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