Structure of PDB 6tz8 Chain B

Receptor sequence
>6tz8B (length=174) Species: 235443 (Cryptococcus neoformans var. grubii H99) [Search protein sequence]
GAAESSMFNSLEKNSNFSGPELMRLKKRFMKLDKDGSGSIDKDEFLQIPQ
IANNPLAHRMIAIFDEDGSGTVDFQEFVGGLSAFSSKGGRDEKLRFAFKV
YDMDRDGYISNGELYLVLKQMVGNNLKDQQLQQIVDKTIMEADKDGDGKL
SFEEFTQMVASTDIVKQMTLEDLF
3D structure
PDB6tz8 Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D34 D36 S38 S40 E45 D33 D35 S37 S39 E44
BS02 CA B D66 D68 S70 T72 E77 D65 D67 S69 T71 E76
BS03 CA B D103 D105 D107 Y109 E114 D102 D104 D106 Y108 E113
BS04 CA B D144 D146 D148 K150 E155 D143 D145 D147 K149 E154
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity
GO:0019902 phosphatase binding
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0097720 calcineurin-mediated signaling
Cellular Component
GO:0005955 calcineurin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tz8, PDBe:6tz8, PDBj:6tz8
PDBsum6tz8
PubMed31537789
UniProtJ9VL81

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