Structure of PDB 6tyk Chain B

Receptor sequence
>6tykB (length=184) Species: 309803 (Thermotoga neapolitana DSM 4359) [Search protein sequence]
MLYDLAKKRKTVRRFKKEKPPLEDLIYSLKVANEAPSGMNAQPWRFLIVE
DEKLKGQIRRVCERSEKTFYENVRGRLKEWLDEKRFTWRKPFLKEAPYLL
LVFSEKSAPYSRESVWLAVGYLLLALEEKGLGSVPYTPPDFREVEKLVNT
PSELRLEVILPVGYPDDPKPKYPRNEVIVRYNTF
3D structure
PDB6tyk Structure of Tn IYD bound in the semiquinone form bound to FMN and 3-iodo-L-tyrosine
ChainB
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.1.1: iodotyrosine deiodinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B P38 S39 G40 N42 Y112 S116 P36 S37 G38 N40 Y110 S114
BS02 IYR B G40 M41 G38 M39
BS03 FMN B K12 T13 R15 F88 W118 P137 Y138 T139 K173 Y174 R176 K10 T11 R13 F86 W116 P135 Y136 T137 K171 Y172 R174
BS04 IYR B E68 Y72 L83 F88 K92 E66 Y70 L81 F86 K90
BS05 IYR B R114 E115 R112 E113
Gene Ontology
Molecular Function
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0072545 L-tyrosine binding
GO:0140616 iodotyrosine deiodinase activity
Biological Process
GO:0006570 tyrosine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6tyk, PDBe:6tyk, PDBj:6tyk
PDBsum6tyk
PubMed
UniProtB9K712|IYD_THENN Iodotyrosine deiodinase (Gene Name=IYD)

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