Structure of PDB 6ty5 Chain B

Receptor sequence
>6ty5B (length=743) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITN
ESFQGLQNLTKINLNHNPNGLNITDGAFLNLKNLRELLLEDNQLPQIPSG
LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYCEKTNIEDGVF
ETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLIN
LTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSST
SLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN
YIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS
TINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVDPHSNFYHFTRPL
IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGT
EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVT
HHLEFIQNFTNLKVLNLSHNNIYTLTKYNLESKSLVELVFSGNRLDILWN
DDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM
LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRIS
HLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE
CTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB6ty5 Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
ChainB
Resolution2.793 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O0W B F261 F346 Y348 G351 S352 V378 F405 F214 F299 Y301 G304 S305 V331 F358 BindingDB: IC50=400nM
BS02 O0W B F494 F495 A518 Y567 F420 F421 A444 Y493 BindingDB: IC50=400nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ty5, PDBe:6ty5, PDBj:6ty5
PDBsum6ty5
PubMed32786235
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

[Back to BioLiP]