Structure of PDB 6tqf Chain B

Receptor sequence

>6tqfB (length=634) Species: 1773 (Mycobacterium tuberculosis)

MGPKLFKPSIDWSRAFPDSVYWVGKAWTISAICVLAILVLLRYLTPWGRQ
FWRITRAYFVGPNSVRVWLMLGVLLLSVVLAVRLNVLFSYQGNDMYTALQ
KAFEGIASGDGTVKRSGVRGFWMSIGVFSVMAVLHVTRVMADIYLTQRFI
IAWRVWLTHHLTQDWLDGRAYYRDLFIDETIDNPDQRIQQDVDIFTAGAG
GTPNAPSNGTASTLLFGAVQSIISVISFTAILWNLSGTLNIFGVSIPRAM
FWTVLVYVFVATVISFIIGRPLIWLSFRNEKLNAAFRYALVRLRDAAEAV
GFYRGERVEGTQLQRRFTPVIDNYRRYVRRSIAFNGWNLSVSQTIVPLPW
VIQAPRLFAGQIDFGDVGQTATSFGNIHDSLSFFRNNYDAFASFRAAIIR
LHGLVDANEKGRALPAVLTRPSDDESVELNDIEVRTPAGDRLIDPLDVRL
DRGGSLVITGRSGAGKTTLLRSLAELWPYASGTLHRPGGENETMFLSQLP
YVPLGTLRDVVCYPNSAAAIPDATLRDTLTKVALAPLCDRLDEERDWAKV
LSPGEQQRVAFARILLTKPKAVFLDGSTSALDTGLEFALYQLLRSELPDC
IVISVSHRPALERLHENQLELLGGGQWRLAPVEA

3D structure

• PDB: 6tqf A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.
• Chain: B
• Resolution: 3.5 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	T467 Q498	T467 Q498
BS02	ANP	B	S462 G465 K466 T467 T468 Q498	S462 G465 K466 T467 T468 Q498

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0052572 response to host immune response
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005576 extracellular region
• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6tqf, PDBe:6tqf, PDBj:6tqf
• PDBsum: 6tqf
• PubMed: 32296172
• UniProt: P9WQI9|BACA_MYCTU Hydrophilic compounds import ATP-binding/permease protein BacA (Gene Name=bacA)