Structure of PDB 6tq7 Chain B

Receptor sequence
>6tq7B (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
AASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRN
HHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPY
LQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLA
IMVPQAAVMECSSFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAY
FQIFRKLWGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVL
NVLKRVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFRE
QFKAAFSWWLP
3D structure
PDB6tq7 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainB
Resolution2.6636 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW B V177 P178 W206 F219 V153 P154 W171 F184
BS02 NVK B S103 Q126 A127 Q179 F219 T223 S79 Q102 A103 Q155 F184 T188 BindingDB: IC50=40nM,Ki=14nM
BS03 NVK B S103 V130 Y311 I314 S315 N318 H344 S79 V106 Y244 I247 S248 N251 H277 BindingDB: IC50=40nM,Ki=14nM
BS04 PGW B L230 A234 Q237 L195 A199 Q202
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tq7, PDBe:6tq7, PDBj:6tq7
PDBsum6tq7
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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