Structure of PDB 6tp6 Chain B

Receptor sequence
>6tp6B (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
KQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLAD
VLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL
DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPEL
AARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKL
WGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF
GMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFS
WWL
3D structure
PDB6tp6 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainB
Resolution2.338 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW B A174 V177 Y215 A132 V135 Y173
BS02 NT5 B A102 S103 I122 P123 Q126 V130 Q179 Y311 H344 Y348 A60 S61 I80 P81 Q84 V88 Q137 Y237 H270 Y274 BindingDB: Ki=2.5nM,IC50=16nM
BS03 PGW B L230 M233 A234 Q237 R240 R245 L188 M191 A192 Q195 R198 R203
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6tp6, PDBe:6tp6, PDBj:6tp6
PDBsum6tp6
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

[Back to BioLiP]