Structure of PDB 6tp4 Chain B

Receptor sequence
>6tp4B (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
AWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVLA
TAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRW
YAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAAR
TRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGR
QIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF
RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL
3D structure
PDB6tp4 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainB
Resolution3.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW B A174 P178 W206 Y215 A129 P133 W161 Y170
BS02 PGW B V222 A226 L230 M233 A234 Q237 V177 A181 L185 M188 A189 Q192
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tp4, PDBe:6tp4, PDBj:6tp4
PDBsum6tp4
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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