Structure of PDB 6tot Chain B

Receptor sequence
>6totB (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
KQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLAD
VLATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL
DRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPEL
AARTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKL
WGRQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVF
GMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFS
WWL
3D structure
PDB6tot Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW B S138 M233 A234 Q237 S96 M191 A192 Q195
BS02 PGW B A174 M176 V177 A181 W206 I214 Y215 C218 A132 M134 V135 A139 W164 I172 Y173 C176
BS03 NRK B A102 S103 P123 Q126 F219 I314 H344 A60 S61 P81 Q84 F177 I240 H270 BindingDB: Ki=2.5nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tot, PDBe:6tot, PDBj:6tot
PDBsum6tot
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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