Structure of PDB 6tor Chain B

Receptor sequence
>6torB (length=404) Species: 9606 (Homo sapiens) [Search protein sequence]
IKIVRAQRQYMFDENGEQYLDCINNVAHVGHCHPGVVKAALKQMELLNTN
SRFLHDNIVEYAKRLSATLPEKLSVCYFTNSGSEANDLALRLARQFRGHQ
DVITLDHAYHGHLSSLIEISPYKFQVKKEFVHVAPTPDTYRGKYREDHAD
SASAYADEVKKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAE
YVHGAGGVFIADEVQVGFGRVGKHFWSFQMYGEDFVPDIVTMGKPMGNGH
PVACVVTTKEIAEAFSSSNTYGGNPVSCAVGLAVLDIIENEDLQGNAKRV
GNYLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHLKRTPATAEAQHII
YKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLDRILTVLEEA
MGTK
3D structure
PDB6tor Structural characterization of human O-phosphoethanolamine phospho-lyase.
ChainB
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y139 D246 K278
Catalytic site (residue number reindexed from 1) Y109 D212 K244
Enzyme Commision number 4.2.3.2: ethanolamine-phosphate phospho-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP B S111 G112 S113 Y139 H140 H142 D246 Q249 S81 G82 S83 Y109 H110 H112 D212 Q215
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0050459 ethanolamine-phosphate phospho-lyase activity
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6tor, PDBe:6tor, PDBj:6tor
PDBsum6tor
PubMed32254049
UniProtQ8TBG4|AT2L1_HUMAN Ethanolamine-phosphate phospho-lyase (Gene Name=ETNPPL)

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