Structure of PDB 6tod Chain B

Receptor sequence
>6todB (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
DEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMR
TVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQTV
SVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMVP
QAAVMECSSVFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQI
FRKLWGRPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKR
VFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAA
FSWWLPGLAAA
3D structure
PDB6tod Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGW B A174 M176 V177 A181 Y215 A146 M148 V149 A153 Y177
BS02 7MA B P123 Q126 V130 Q179 F219 I314 N318 H344 V347 Y348 P95 Q98 V102 Q151 F181 I242 N246 H272 V275 Y276 BindingDB: Ki=900nM,IC50=>10000nM
BS03 PGW B M233 A234 Q237 M195 A196 Q199
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6tod, PDBe:6tod, PDBj:6tod
PDBsum6tod
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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