Structure of PDB 6tmh Chain B

Receptor sequence
>6tmhB (length=479) Species: 507601 (Toxoplasma gondii GT1) [Search protein sequence]
TNHGRITQVIGAVVDVHFDEQLPPILNSLEVQGHTNRLVLEVAQHLGENT
VRTIAMDATEGLVRGQKVVDTGAPIQVPVGVETLGRIMNVIGEPVDECGP
VPAKKTYSIHRAAPLFADQSTEPGLLQTGIKVVDLLAPYAKGGKIGLFGG
AGVGKTVLIMELINNVANKHGGFSVFAGVGERTREGNDLYHEMMTTGVIK
RKKLEDGKFDFTGSKAALVYGQMNEPPGARARVALTALSVAEYFRDEQGQ
DVLLFIDNIYRFTQAGSEVSALLGRIPSAVGYQPTLATDLGQLQERITTT
KKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRQIAELGIYPAVD
PLDSTSRMLAPEIVGQEHYDTARATQKLLQDYKSLQDIIAILGMDELSEE
DKLVVSRARKIQRFLSQPFTVAEVFTGKPGRFVELPETIKSAQTILRGEC
DDLPEMAFYMCGGLEEVRSKAVKMAQEAA
3D structure
PDB6tmh ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K233 E259 R260 R435
Catalytic site (residue number reindexed from 1) K155 E181 R182 R357
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G230 G232 K233 T234 V235 Y424 G152 G154 K155 T156 V157 Y346
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0009507 chloroplast
GO:0016020 membrane
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Molecular Function
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Cellular Component
External links
PDB RCSB:6tmh, PDBe:6tmh, PDBj:6tmh
PDBsum6tmh
PubMed33402698
UniProtA0A125YYY4

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