Structure of PDB 6tbb Chain B

Receptor sequence
>6tbbB (length=261) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
GSHMASLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSR
KELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIA
FANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVAT
TYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRT
LSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGEN
IHVDSGFHAIK
3D structure
PDB6tbb The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.39: enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B G13 I14 A15 S19 I20 R40 S44 D66 V67 S93 I94 A95 T145 T146 K164 A190 P192 I193 T195 S197 G18 I19 A20 S24 I25 R45 S49 D71 V72 S98 I99 A100 T150 T151 K169 A195 P197 I198 T200 S202
BS02 KAL B A95 F96 A97 Y157 S197 I207 A100 F101 A102 Y162 S202 I212
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6tbb, PDBe:6tbb, PDBj:6tbb
PDBsum6tbb
PubMed32208550
UniProtQ6GI75|FABI_STAAR Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Gene Name=fabI)

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