Structure of PDB 6t7h Chain B

Receptor sequence
>6t7hB (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
3D structure
PDB6t7h Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries.
ChainB
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MRQ B H57 Y60A W60D N98 L99 I174 D189 A190 E192 W215 G216 E217 G219 H43 Y47 W50 N95 L96 I179 D199 A200 E202 W227 G228 E229 G230
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6t7h, PDBe:6t7h, PDBj:6t7h
PDBsum6t7h
PubMed34094158
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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