Structure of PDB 6t2c Chain B

Receptor sequence
>6t2cB (length=626) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHKKRVKLTKKNYLIRAL
TLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVELLARNICERLEQSGLP
VGGNEKKAKLANVIKKMMAKSTDEELSYTITGDNTKWNENQNPRIFLAMV
LRITAGQPEWFRDLLAVAPIMFSNKVARLGRGYMFESKSMHLRTQISAEN
LSDINLRYFNEDTKKKIEKIRHLMVEGTASLSPGMMMGMFNMLSTVLGVS
VLNLGQREILKRTYWWDGLQSSDDFALIINGHFKEDIQQGVNHFYRTCKL
VGINMSQKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVAGNNESAD
MSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYTYRCHRGDTNLETRR
TKSIKRLWTETISKAGLLVADGGPNPYNLRNLHIPEVCLKWSLMDPDYRG
RLCNPNNPFVYDAVATTHSWTPKRNR
3D structure
PDB6t2c A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
ChainB
Resolution3.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B H32 T34 Y38 M356 R365 K553 Y557 R560 L568 E569 R571 H32 T34 Y38 M334 R343 K531 Y535 R538 L546 E547 R549
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t2c, PDBe:6t2c, PDBj:6t2c
PDBsum6t2c
PubMed32304664
UniProtH6QM91

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