Structure of PDB 6svq Chain B

Receptor sequence
>6svqB (length=640) Species: 9606 (Homo sapiens) [Search protein sequence]
CGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWE
ANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGE
PSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTET
IAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGT
RRGSPLLIGVRSEHKLSTDHIPILYRTTCLFPVEEKAVEYYFASDASAVI
EHTNRVIFLEDDDVAAVVDGRLSIHRELQQIMKGNFSSFMQKEIFEQPES
VVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATR
QVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSGETADTLMGLRY
CKERGALTVGITNTVGSSISRETDCEVHINAGPEIGVASTKAYTSQFVSL
VMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELY
HQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDK
LMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTI
KVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLA
3D structure
PDB6svq Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
ChainB
Resolution2.717 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L8 R33 W96 N123 G124 E554 K558 E561 H577
Catalytic site (residue number reindexed from 1) L7 R32 W95 N122 G123 E519 K523 E526 H542
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G6Q B G375 T376 S377 S421 Q422 S423 T426 S474 K558 E561 G340 T341 S342 S386 Q387 S388 T391 S439 K523 E526
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
GO:1901137 carbohydrate derivative biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6svq, PDBe:6svq, PDBj:6svq
PDBsum6svq
PubMed32019926
UniProtQ06210|GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (Gene Name=GFPT1)

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