Structure of PDB 6svo Chain B

Receptor sequence
>6svoB (length=657) Species: 9606 (Homo sapiens) [Search protein sequence]
CGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWE
ANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGE
PSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTET
IAKLVKYMYDNRESQDTSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGT
RRGSPLLIGVRSEHKLSTDHIPILYRVDSTTCLFPVEEKAVEYYFASDAS
AVIEHTNRVIFLEDDDVAAVVDGRLSIHRRAVQTLQMELQQIMKGNFSSF
MQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIAC
GTSYHAGVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFLSQSG
ETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVAS
TKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMD
DEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGE
LKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKED
TETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNL
AKSVTVE
3D structure
PDB6svo Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
ChainB
Resolution2.328 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L8 R33 W96 N123 G124 E554 K558 E561 H577 K676
Catalytic site (residue number reindexed from 1) L7 R32 W95 N122 G123 E530 K534 E537 H553 K652
Enzyme Commision number 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGP B T376 S421 Q422 S423 T426 S474 K558 E561 T352 S397 Q398 S399 T402 S450 K534 E537
Gene Ontology
Molecular Function
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0097367 carbohydrate derivative binding
Biological Process
GO:1901135 carbohydrate derivative metabolic process
GO:1901137 carbohydrate derivative biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6svo, PDBe:6svo, PDBj:6svo
PDBsum6svo
PubMed32019926
UniProtQ06210|GFPT1_HUMAN Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (Gene Name=GFPT1)

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