Structure of PDB 6st3 Chain B

Receptor sequence
>6st3B (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTK
AMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFP
EGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERA
RAKVKYLTG
3D structure
PDB6st3 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
ChainB
Resolution2.426 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H313 D315 H374 H116 D118 H177
BS02 LUW B R252 T296 Y303 Y310 H313 D315 D320 R322 H374 V376 W389 F391 R55 T99 Y106 Y113 H116 D118 D123 R125 H177 V179 W192 F194 MOAD: ic50=0.256uM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6st3, PDBe:6st3, PDBj:6st3
PDBsum6st3
PubMed31751494
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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