Structure of PDB 6sq0 Chain B

Receptor sequence
>6sq0B (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
LTADQMVSALLDAEPPILYSEYEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
SVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGDHIHRVLDK
ITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKPS
YDLLLEMLDA
3D structure
PDB6sq0 Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.
ChainB
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LRQ B L346 T347 A350 E353 L384 R394 F404 M421 G521 L525 L30 T31 A34 E37 L68 R78 F88 M105 G190 L194 MOAD: ic50=0.00000001M
BindingDB: IC50=16nM
External links
PDB RCSB:6sq0, PDBe:6sq0, PDBj:6sq0
PDBsum6sq0
PubMed31620239
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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