Structure of PDB 6slt Chain B

Receptor sequence
>6sltB (length=525) Species: 1887 (Streptomyces albogriseolus) [Search protein sequence]
DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEAT
VPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLD
DGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIM
NAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEV
LTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHL
LCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSD
HFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLAS
CFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTR
DFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDE
GTNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAELLFA
DVKRKGDTLVESLPSTYDLLRQLHG
3D structure
PDB6slt Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.19.59: tryptophan 6-halogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 B R439 R483 R438 R479
BS02 FAD B G12 G13 G14 T15 A16 E38 A39 I42 R44 I45 V47 G48 A50 E197 M198 C228 S229 G230 L234 W285 L349 F353 P356 G361 I362 G11 G12 G13 T14 A15 E37 A38 I41 R43 I44 V46 G47 A49 E196 M197 C227 S228 G229 L233 W284 L348 F352 P355 G360 I361
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6slt, PDBe:6slt, PDBj:6slt
PDBsum6slt
PubMed31589794
UniProtA1E280|TRP6H_STRAO Tryptophan 6-halogenase ThaL (Gene Name=thaL)

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