Structure of PDB 6siy Chain B

Receptor sequence

>6siyB (length=436) Species: 1470557 (Streptomyces sp. Tu 6176) [Search protein sequence]

MSRSRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRT
ADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYT
EEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATV
VPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQ
DFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPE
GRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADD
VEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAY
EVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLA
PGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF

3D structure

PDB

6siy The Biosynthesis of the Benzoxazole in Nataxazole Proceeds via an Unstable Ester and has Synthetic Utility.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	B	G147 T149	G147 T149
BS02	MG	B	R78 E79	R78 E79
BS03	AMP	B	S88 A212 E213 P214 E235 Y236 G237 S238 T239 D299 V319	S88 A212 E213 P214 E235 Y236 G237 S238 T239 D299 V319
BS04	3HA	B	L138 A211 E235 G237 S238 T239	L138 A211 E235 G237 S238 T239
BS05	ZN	B	C248 H254 C308 C310	C248 H254 C308 C310
BS06	3HA	B	T128 P129 T135 R156 N180	T128 P129 T135 R156 N180

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6siy, PDBe:6siy, PDBj:6siy
PDBsum	6siy
PubMed	31903677
UniProt	A0A022MRT4

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