Structure of PDB 6s86 Chain B

Receptor sequence
>6s86B (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYAVSQRLYILLPLDCGVP
DNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVL
EYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNC
RLIAYQEFSLSQEVLRHLRQ
3D structure
PDB6s86 No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E B Y163 Y167 R232 I235 R238 Y240 S241 T263 Y10 Y14 R73 I76 R79 Y81 S82 T104 BindingDB: EC50=4500nM,Kd=1210nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6s86, PDBe:6s86, PDBj:6s86
PDBsum6s86
PubMed31475926
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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