Structure of PDB 6s3h Chain B

Receptor sequence

>6s3hB (length=423) Species: 751945 (Thermus oshimai JL-2) [Search protein sequence]

LSSEQQRAFLAVTQTPHPAHLITGPAGTGKTTLLYALQEFYKGRAVTLAP
TGTAALQARGQTVHSFFRFPARLLRYRHPEDIRPPGPHSPLRKAIEQMEV
LILDEVGMVRVDLLEAMDWALRKTRKRLEEPFGGVKVLLLGDTRQLEPVV
PGGEEALYIARTWGGPFFFQAHVWEEVALRVHRLWESQRQREDPLFAELL
KRLRQGDPQALETLNRAAVRPDGGEEPGTLILTPRRKEADALNLKRLEAL
PGKPLEYQAQVKGEFAETDFPTEAALTLKKGAQVILLRNDPLGEYFNGDL
GWVEDLEAEALAVRLKRNGRRVVIRPFVWEKIVPQVVGTFRQVPVRLAWA
LTVHKAQGLTLDKVHLELGRGLFAHGQLYVALTRVRRLQDLSLSRPIAPT
ELLWRPEVEVFETRIQEGIWQKS

3D structure

PDB

6s3h Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.

Chain

Resolution

2.06 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	P117 G119 T129 H131 A138 V216 V217 G219 R302 R303 T430 H432 K433 F451	P50 G52 T62 H64 A71 V149 V150 G152 R235 R236 T352 H354 K355 F373
BS02	ADP	B	Q72 G94 G96 K97 T98 T99 Q255 R256	Q5 G27 G29 K30 T31 T32 Q188 R189
BS03	ALF	B	A93 G94 K97 E172 Q212 R256 G436 R462	A26 G27 K30 E105 Q145 R189 G358 R384

Gene Ontology

	Molecular Function
GO:0003678	DNA helicase activity
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000723	telomere maintenance
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6s3h, PDBe:6s3h, PDBj:6s3h
PDBsum	6s3h
PubMed	33784404
UniProt	K7RJ88

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