Structure of PDB 6s0h Chain B

Receptor sequence
>6s0hB (length=216) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
LPDLKIEKLEEGVFVHTSFEEVNGWGVVTKHGLVVLVNTDAYLIDTPFTA
TDTEKLVNWFVERGYEIKGTISSHFHSDSTGGIEWLNSQSIPTYASELTN
ELLKKSGKVQAKYSFSEVSYWLVKNKIEVFYPGPGHTQDNLVVWLPESKI
LFGGCFIKPHGLGNLGDANLEAWPKSAKILMSKYGKAKLVVSSHSEKGDA
SLMKRTWEQALKGLKE
3D structure
PDB6s0h Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase.
ChainB
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H77 H79 D81 H139 C158 K161 N167 H197
Catalytic site (residue number reindexed from 1) H74 H76 D78 H136 C155 K158 N164 H194
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H77 H79 H139 H74 H76 H136
BS02 ZN B D81 C158 H197 D78 C155 H194
BS03 KQ8 B W28 V31 T32 H79 D81 H139 C158 K161 G166 N167 H197 W25 V28 T29 H76 D78 H136 C155 K158 G163 N164 H194
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s0h, PDBe:6s0h, PDBj:6s0h
PDBsum6s0h
PubMed32205343
UniProtQ7WYA8|BLAB_PSEAI Metallo-beta-lactamase type 2 (Gene Name=bla-imp13)

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