Structure of PDB 6rxp Chain B

Receptor sequence
>6rxpB (length=235) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEDKCHCCQFPAPLRPHVVW
FGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL
NLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK
3D structure
PDB6rxp Evolved, Selective Erasers of Distinct Lysine Acylations.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E73 E79 R83 G191 E34 E40 R44 G152
BS02 peptide B F60 C131 H147 V188 F190 G191 E192 M193 Y201 H218 V219 Y220 P221 F21 C92 H108 V149 F151 G152 E153 M154 Y162 H179 V180 Y181 P182
BS03 ZN B C155 C174 C177 C116 C135 C138
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxp, PDBe:6rxp, PDBj:6rxp
PDBsum6rxp
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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