Structure of PDB 6rv4 Chain B

Receptor sequence

>6rv4B (length=258) Species: 9606 (Homo sapiens)

MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRA
RYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAA
PSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGAD
VSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFG
DYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAED
EKRDAENL

3D structure

• PDB: 6rv4 A lower X-gate in TASK channels traps inhibitors within the vestibule.
• Chain: B
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	B	I94 G95 Y96 I200 G201	I94 G95 Y96 I197 G198
BS02	K	B	T93 I94 T199 I200 G201	T93 I94 T196 I197 G198
BS03	K	B	T93 T199	T93 T196
BS04	KKZ	B	T93 I118 L122 L197 T198 T199 I235 L239	T93 I118 L122 L194 T195 T196 I232 L236	BindingDB: IC50=42.0nM
BS05	K	B	G95 Y96 G97 G201 F202 G203	G95 Y96 G97 G198 F199 G200
BS06	Y01	B	R3 L11 F246	R3 L11 F243
BS07	Y01	B	R79 F80 A81 Q215 A222	R79 F80 A81 Q212 A219

Gene Ontology

Molecular Function

• GO:0005252 open rectifier potassium channel activity
• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6rv4, PDBe:6rv4, PDBj:6rv4
• PDBsum: 6rv4
• PubMed: 32499642
• UniProt: O14649|KCNK3_HUMAN Potassium channel subfamily K member 3 (Gene Name=KCNK3)