Structure of PDB 6ru8 Chain B

Receptor sequence

>6ru8B (length=293) Species: 9606 (Homo sapiens)

ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK

3D structure

• PDB: 6ru8 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
• Chain: B
• Resolution: 1.92 Å

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.
  2.7.11.26: [tau protein] kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	S19 F20 H46 Q48 I51 E52 I55 D128 K130 F150 G151 L152 T174 G175 T176 R178 Q214 G215 K224 Y225	S18 F19 H45 Q47 I50 E51 I54 D127 K129 F149 G150 L151 T173 G174 T175 R177 Q213 G214 K223 Y224
BS02	ADP	B	S17 G18 I23 A36 K38 E52 Y56 M82 L85 D149	S16 G17 I22 A35 K37 E51 Y55 M81 L84 D148

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6ru8, PDBe:6ru8, PDBj:6ru8
• PDBsum: 6ru8
• PubMed: 32719556
• UniProt: P48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)