Structure of PDB 6ru6 Chain B

Receptor sequence
>6ru6B (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKM
MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLL
ADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRQ
HIPYRENKGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGL
KAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDY
SYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB6ru6 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B I23 A36 M82 L85 L135 I15 A28 M74 L77 L127
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ru6, PDBe:6ru6, PDBj:6ru6
PDBsum6ru6
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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