Structure of PDB 6rpg Chain B

Receptor sequence
>6rpgB (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQF
VHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMIS
YGGADYKRITVKVNAPY
3D structure
PDB6rpg Design, Synthesis, Evaluation, and Structural Studies ofC2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KDW B Y56 Q66 M115 I116 S117 A121 D122 Y123 Y39 Q49 M98 I99 S100 A104 D105 Y106 PDBbind-CN: -logKd/Ki=8.52,IC50=3.0nM
BindingDB: IC50=3.0nM,EC50=763nM
External links
PDB RCSB:6rpg, PDBe:6rpg, PDBj:6rpg
PDBsum6rpg
PubMed31298541
UniProtQ9NZQ7|PD1L1_HUMAN Programmed cell death 1 ligand 1 (Gene Name=CD274)

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