Structure of PDB 6rna Chain B

Receptor sequence
>6rnaB (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
EAICSALPTIPYHKLADLRYLSRGTVSSARHADWRVQVAVKHLDSERKDV
LREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEY
PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIA
DFGLSKWRMEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRK
QPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQN
PDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB6rna Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
ChainB
Resolution2.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D133 Q137 N138 D151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KA2 B L24 S25 V32 A45 K47 E66 L79 T95 Y97 M98 G101 E105 L153 A163 D164 L21 S22 V26 A39 K41 E53 L66 T82 Y84 M85 G88 E92 L140 A150 D151 BindingDB: IC50=0.002000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6rna, PDBe:6rna, PDBj:6rna
PDBsum6rna
PubMed31265286
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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