Structure of PDB 6rkf Chain B

Receptor sequence
>6rkfB (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
DTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGML
IPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQST
PTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKYEGPAYLPWLE
KRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRG
QVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENS
REILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVV
HHYGHGSGGISVHWGTALEAARLVSECVHALRTP
3D structure
PDB6rkf Structure and kinetic properties of human d-aspartate oxidase, the enzyme-controlling d-aspartate levels in brain.
ChainB
Resolution3.219 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M50 S308 S312
Catalytic site (residue number reindexed from 1) M49 S307 S311
Enzyme Commision number 1.4.3.1: D-aspartate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G10 G12 V13 V14 S35 D36 K37 T42 T43 S44 A47 A48 R165 I166 S183 L190 G276 L277 R278 S308 G310 I311 G9 G11 V12 V13 S34 D35 K36 T41 T42 S43 A46 A47 R164 I165 S182 L189 G275 L276 R277 S307 G309 I310
Gene Ontology
Molecular Function
GO:0003884 D-amino-acid oxidase activity
GO:0005515 protein binding
GO:0008445 D-aspartate oxidase activity
GO:0016491 oxidoreductase activity
GO:0047821 D-glutamate oxidase activity
GO:0071949 FAD binding
Biological Process
GO:0006531 aspartate metabolic process
GO:0006533 aspartate catabolic process
GO:0007320 insemination
GO:0007625 grooming behavior
GO:0010646 regulation of cell communication
GO:0019478 D-amino acid catabolic process
GO:0042445 hormone metabolic process
GO:0046416 D-amino acid metabolic process
GO:0050877 nervous system process
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rkf, PDBe:6rkf, PDBj:6rkf
PDBsum6rkf
PubMed31914658
UniProtQ99489|OXDD_HUMAN D-aspartate oxidase (Gene Name=DDO)

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