Structure of PDB 6rih Chain B

Receptor sequence
>6rihB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
LRKVLISDSLDPCCRKILGLQVVEKQNLSKEELIAECEGLIVRSATKVTA
DVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTC
GMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVA
TRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLP
STTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDV
FTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMV
3D structure
PDB6rih Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K4T B G151 Y173 D174 P175 I176 I177 T206 P207 L215 G141 Y163 D164 P165 I166 I167 T196 P197 L205 MOAD: Kd=105uM
BindingDB: Kd=105000nM
Gene Ontology
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6rih, PDBe:6rih, PDBj:6rih
PDBsum6rih
PubMed31365252
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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