Structure of PDB 6rfs Chain B

Receptor sequence
>6rfsB (length=456) Species: 4952 (Yarrowia lipolytica) [Search protein sequence]
RQYGGLKDQDRIFQNLYDNYGWDLASARKQGDWYKTKELILKGDTWIIDE
IKKSGLRGRGGAGFPSGLKWSFMNPPGWEKNEGPRYLVVNADEGEPGTCK
DREIMRKDPHKLVEGCLLAGRAMNATAAYIYIRGEFYNEAAVLQTAINEA
YAAGLIGKDACGSGYDFDVYIHRGMGAYVCGEETSLIESLEGKAGKPRLK
PPFPAGVGLFGRPSTVTNVETVAVAPTILRRGGDWFASFGRERNSGTKLF
CISGNVNEPCTVEEEMSIPLRELLEKHCGGIKGGWDNLLGVIPGGCSVPI
LPKNICEDVLMDFDALKDVQSGLGTAAVIVINKQQDVIRAIQRFAAFYKH
ESCGQCTPCREGTTWLLKAMDRFRTGQAKEREIDMLYELTKDIEGHTICA
LGDAAAWPIQGLIRNFRPEMETRMKKFHDEVGAVSVGGWMKDARVEKGKV
VGAPLP
3D structure
PDB6rfs High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease.
ChainB
Resolution4.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 B S380 C381 G382 Q383 C384 C387 T425 C427 L429 S352 C353 G354 Q355 C356 C359 T397 C399 L401
BS02 FMN B G86 G88 A90 K97 N118 D120 G209 E210 E211 T245 N246 G58 G60 A62 K69 N90 D92 G181 E182 E183 T217 N218
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rfs, PDBe:6rfs, PDBj:6rfs
PDBsum6rfs
PubMed31844670
UniProtF2Z660

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