Structure of PDB 6ra4 Chain B

Receptor sequence
>6ra4B (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
GPTAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEI
THCGQMKRKYRVCNVTRRPASHQTFPLQTVECTVAQYFKDRHKLVLRYPH
LPCLQVGQEQKHTYLPLEVCNIVAGQRCIK
3D structure
PDB6ra4 How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q266 K268 Q55 K57
BS02 rna B F216 H263 M267 R269 Y271 R272 F286 Y303 R307 H308 K327 H328 T329 Y330 G341 F5 H52 M56 R58 Y60 R61 F75 Y87 R91 H92 K111 H112 T113 Y114 G125
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6ra4, PDBe:6ra4, PDBj:6ra4
PDBsum6ra4
PubMed31021613
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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