Structure of PDB 6r6u Chain B

Receptor sequence
>6r6uB (length=457) Species: 9606 (Homo sapiens) [Search protein sequence]
SITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIAS
QYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHP
SGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDM
PKRFHPPSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAAT
QTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVL
PSIASYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKHLVAERALLPTD
YIKRIVLRIPNVQYVNRPFPVSEHEARHSFQYVACAMLLDGGITVPSFHE
CQINRPQVRELLSKVELEYPPDNLPSFNILYCEISVTLKDGATFTDRSDT
FYGHWRKPLSQEDLEEKFRANASKMLSWDTVESLIKIVKNLEDLEDCSVL
TTLLKGP
3D structure
PDB6r6u Crystal structure ofcis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.
ChainB
Resolution1.705 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.6: cis-aconitate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BU3 B Q317 Y318 Q313 Y314
BS02 BU3 B T397 F398 T393 F394
BS03 BU3 B A151 F158 P160 A147 F154 P156
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0047613 aconitate decarboxylase activity
Biological Process
GO:0002760 positive regulation of antimicrobial humoral response
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007566 embryo implantation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0045087 innate immune response
GO:0045824 negative regulation of innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0051607 defense response to virus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071346 cellular response to type II interferon
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071393 cellular response to progesterone stimulus
GO:0072573 tolerance induction to lipopolysaccharide
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r6u, PDBe:6r6u, PDBj:6r6u
PDBsum6r6u
PubMed31548418
UniProtA6NK06|IRG1_HUMAN Cis-aconitate decarboxylase (Gene Name=ACOD1)

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