Structure of PDB 6r65 Chain B

Receptor sequence
>6r65B (length=623) Species: 9606 (Homo sapiens) [Search protein sequence]
FTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETL
ENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDN
NDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTS
GIVIQVFPLHDSEALKKLEDTWYTKYQPIDSIRGYFGETIALYFGFLEYF
TFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANM
TYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVS
LPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAI
VIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFY
IAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQ
ALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLA
AAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVV
TNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPR
HIQMKLARLEFESLEALKQQQMK
3D structure
PDB6r65 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B N444 Q445 E448 E500 E529 N426 Q427 E430 E482 E511
BS02 CA B E448 D497 E500 E529 D533 E430 D479 E482 E511 D515
BS03 CA B E259 A610 I613 D615 E241 A592 I595 D597
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Biological Process
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Cellular Component
External links
PDB RCSB:6r65, PDBe:6r65, PDBj:6r65
PDBsum6r65
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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