Structure of PDB 6r5f Chain B

Receptor sequence
>6r5fB (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
IKMKSSDFLVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLR
HSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILE
IIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNG
TLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLI
MAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPF
YLSQLE
3D structure
PDB6r5f Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
ChainB
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D117 K119 E121 N122 D135 T151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JSW B K45 M67 V75 V76 M92 L129 H136 I154 A155 D156 S161 F162 K24 M46 V54 V55 M71 L108 H115 I133 A134 D135 S140 F141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6r5f, PDBe:6r5f, PDBj:6r5f
PDBsum6r5f
PubMed31013427
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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