Structure of PDB 6qzv Chain B

Receptor sequence
>6qzvB (length=805) Species: 9606 (Homo sapiens) [Search protein sequence]
PAARFQVQKHSWDGLRSIIHGSRKKAPHDFQFVQKTDESGPHSHRLYYLG
MPRENSLLYSEIPKKLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLG
VFGITSYDFHSESGLFLFQASNSLFHCRDGFMVSPMKPLEIKTQCSGPRM
DPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQVLDDPKSAGVAT
FVIQEEFDRFTGYWWCPTASWLKTLRILYEEVDESEVEVIHVPSPALEER
KTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPK
VEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLA
SARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEDELCFLRANECKTG
FCHLYKVTAVLKSQGYDWSEPFSPGFKCPIKEEIALTSGEWEVLARHGSK
IWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMS
QNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEADYVPP
EIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKG
IKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEG
LQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTV
WMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLD
ENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHF
LQEYL
3D structure
PDB6qzv Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y644 S730 Y731 D808 H840
Catalytic site (residue number reindexed from 1) Y586 S672 Y673 D750 H782
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E248 E249 S730 Y762 Y766 N810 H840 E205 E206 S672 Y704 Y708 N752 H782
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0043069 negative regulation of programmed cell death
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031252 cell leading edge

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzv, PDBe:6qzv, PDBj:6qzv
PDBsum6qzv
PubMed
UniProtQ86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 (Gene Name=DPP9)

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