Structure of PDB 6qx3 Chain B

Receptor sequence

>6qx3B (length=615) Species: 506350 (Influenza A virus (A/Hong Kong/1/1968(H3N2)))

MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMEIRVNKRSYLIRALTLNTMTK
DAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKK
AKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQ
PEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLK
YFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQK
RYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSK
KKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTV
IKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKL
WEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLN
PFVTTHSWIPKRNRS

3D structure

• PDB: 6qx3 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Chain: B
• Resolution: 3.79 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	H32 G33 T34 M356 R365	H32 G33 T34 M327 R336
BS02	rna	B	Y557 Q569 R571	Y528 Q540 R542

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0034062 5'-3' RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qx3, PDBe:6qx3, PDBj:6qx3
• PDBsum: 6qx3
• PubMed: 31485076
• UniProt: Q910D6|RDRP_I68A4 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)