Structure of PDB 6qv1 Chain B

Receptor sequence

>6qv1B (length=573) Species: 243274 (Thermotoga maritima MSB8)

TATLRRLLGYLRPHTFTLIMVFVFVTVSSILGVLSPYLIGKTIAVVFVPR
RFDLLPRYMLILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELFEKLQ
RVPVGFFDRTPHGDIISRVINDVDNINNVLGNSIIQFFSGIVTLAGAVIM
MFRVNVILSLVTLSIVPLTVLITQIVSSQTRKYFYENQRVLGQLNGIIEE
DISGLTVIKLFTREEKEMEKFDRVNESLRKVGTKAQIFSGVLPPLMNMVN
NLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSNQFNMIQ
MALASAERIFEILDLEEEKDDPDAVELREVRGEIEFKNVWFSYDKKKPVL
KDITFHIKPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGIDIRK
IKRSSLRSSIGIVLQDTILFSTTVKENLKYGNPGATDEEIKEAAKLTHSD
HFIKHLPEGYETVLTDNGEDLSQGQRQLLAITRAFLANPKILILDAATSN
VDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIKNADLIIVLRDGEIVEMG
KHDELIQKRGFYYELFTSQYGLV

3D structure

• PDB: 6qv1 The extracellular gate shapes the energy profile of an ABC exporter.
• Chain: B
• Resolution: 3.48 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AGS	B	D491 S493 G495 Q496	D470 S472 G474 Q475
BS02	AGS	B	Y364 V370 T390 G391 S392 G393 K394 T395 T396 Q436 H548	Y343 V349 T369 G370 S371 G372 K373 T374 T375 Q415 H527
BS03	MG	B	T395 Q436	T374 Q415

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6qv1, PDBe:6qv1, PDBj:6qv1
• PDBsum: 6qv1
• PubMed: 31113958
• UniProt: Q9WYC4|Y288_THEMA Uncharacterized ABC transporter ATP-binding protein TM_0288 (Gene Name=TM_0288)