Structure of PDB 6qrm Chain B

Receptor sequence

>6qrmB (length=391) Species: 9606 (Homo sapiens)

PAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQ
GFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPP
GWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKL
RSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPR
KLIEVKFSHLSNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTR
YLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPS
TIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDL
MENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

• PDB: 6qrm High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V181 E182 D183 F188 R189 F190 N246 T282 R295 Y296 H298 S405 I469 G470 D471 G472 N473 Q496	V77 E78 D79 F84 R85 F86 N142 T178 R191 Y192 H194 S300 I364 G365 D366 G367 N368 Q391
BS02	MYA	B	R115 Y117 Q118 F119 W120 Y180 V181 I245 N246 L248 C249 V250 R255 S256 A260 P261 T268 F277 A279 Y281 T282 L287 Y479	R11 Y13 Q14 F15 W16 Y76 V77 I141 N142 L144 C145 V146 R151 S152 A156 P157 T164 F173 A175 Y177 T178 L183 Y374

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

External links

• PDB: RCSB:6qrm, PDBe:6qrm, PDBj:6qrm
• PDBsum: 6qrm
• PubMed: 32111831
• UniProt: P30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)