Structure of PDB 6qra Chain B

Receptor sequence
>6qraB (length=206) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
SMKIDVVTIFPEYLQPVGLVDVAVHDLRRWTHDVHKSVDDSPYGGGPGMV
MKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGR
YEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVA
SLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDL
LGFDSP
3D structure
PDB6qra Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
ChainB
Resolution1.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P85 E112 R154
Catalytic site (residue number reindexed from 1) P75 E102 R144
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JDK B P83 T84 P85 G109 R110 Y111 E112 S132 I133 G134 Y136 L138 N139 G140 G141 P73 T74 P75 G99 R100 Y101 E102 S122 I123 G124 Y126 L128 N129 G130 G131 MOAD: Kd=710nM
PDBbind-CN: -logKd/Ki=6.15,Kd=710nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qra, PDBe:6qra, PDBj:6qra
PDBsum6qra
PubMed31282680
UniProtB1MDI3

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