Structure of PDB 6qr1 Chain B

Receptor sequence
>6qr1B (length=201) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]
SMKIDVVTIFPEYLQPVRGLVDVAVHDLRRWTSVDDSPYGGGPGMVMKPT
VWGDALDEICTSETLLVVPTPAGYPFTQETAWQWSTEDHLVIACGRYEGI
DQRVADDAATRMRVREVSIGDYVLNGGEAAALVIIEAVLRLVPGVSLLEG
PSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQSRQRTIERRPDLLGFDS
P
3D structure
PDB6qr1 Development of Inhibitors againstMycobacterium abscessustRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
ChainB
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P85 E112 R154
Catalytic site (residue number reindexed from 1) P71 E98 R140
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JFT B P83 T84 P85 G109 R110 Y111 E112 S132 I133 G134 Y136 V137 L138 N139 G140 A144 P69 T70 P71 G95 R96 Y97 E98 S118 I119 G120 Y122 V123 L124 N125 G126 A130 MOAD: Kd=8.5uM
PDBbind-CN: -logKd/Ki=5.07,Kd=8.5uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:6qr1, PDBe:6qr1, PDBj:6qr1
PDBsum6qr1
PubMed31282680
UniProtB1MDI3

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