Structure of PDB 6qpl Chain B

Receptor sequence
>6qplB (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
NIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLE
LNKDERVSALEVLPDRVLADTMIGKAVEHMFETEDGSKDEWRGMVLARAP
VMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPSLVGKQVEYADGSKRT
GMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTSAENLYFQ
3D structure
PDB6qpl Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JC5 B D95 H139 F141 W151 Y170 Y177 Y179 D184 D44 H79 F81 W91 Y110 Y117 Y119 D124 MOAD: ic50=77nM
PDBbind-CN: -logKd/Ki=7.04,Kd=91nM
BindingDB: IC50=77nM,Kd=91nM
Gene Ontology
Biological Process
GO:0007276 gamete generation

View graph for
Biological Process
External links
PDB RCSB:6qpl, PDBe:6qpl, PDBj:6qpl
PDBsum6qpl
PubMed31260300
UniProtQ9Y657|SPIN1_HUMAN Spindlin-1 (Gene Name=SPIN1)

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