Structure of PDB 6qhd Chain B

Receptor sequence
>6qhdB (length=532) Species: 9606 (Homo sapiens) [Search protein sequence]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKR
RQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKG
DPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQF
TTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMN
MEESNNGSLSAEFKHLTLREQRASLIVTEELHLITFETEVYHQGLKIDLE
THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVA
EVLSWQFSSTTKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAGKG
FSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLL
RFSESSKEGGVTFTWVETQIQSVEPYTKQQLNNMSFAEIIMGYKIILVSP
LVYLYPDIPKEEAFGKYCRAPYLKTKFICVTP
3D structure
PDB6qhd Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
ChainB
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R382 I431 V432 S465 N466 R237 I276 V277 S310 N311 PDBbind-CN: Kd=20nM
BS02 dna B M331 H332 K340 V343 Q344 N466 I467 M186 H187 K195 V198 Q199 N311 I312 PDBbind-CN: Kd=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6qhd, PDBe:6qhd, PDBj:6qhd
PDBsum6qhd
PubMed31170499
UniProtP40763|STAT3_HUMAN Signal transducer and activator of transcription 3 (Gene Name=STAT3)

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