Structure of PDB 6qct Chain B

Receptor sequence

>6qctB (length=735) Species: 11520 (Influenza B virus)

GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGF
LIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIR
GFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGIS
MTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIA
RLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEE
GTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALF
VNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDG
FVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQL
FIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYN
LRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEKMDYDAVSGTHS
WRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQHSML
EAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI

3D structure

• PDB: 6qct Structural snapshots of actively transcribing influenza polymerase.
• Chain: B
• Resolution: 3.2 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	H32 G33 T34 L200 K237 K365 I673 N675	H33 G34 T35 L201 K238 K366 I659 N661
BS02	rna	B	G125 R126 Q127 N136 K229 D230 I241 T243 R249 P272 V273 G274 G275 K353 N414 M415 N531	G126 R127 Q128 N137 K230 D231 I242 T244 R250 P273 V274 G275 G276 K354 N415 M416 N532
BS03	rna	B	Y24 Q124 R126 N414 D444 T492 S493 M506 K706	Y25 Q125 R127 N415 D445 T493 S494 M507 K692

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0034062 5'-3' RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qct, PDBe:6qct, PDBj:6qct
• PDBsum: 6qct
• PubMed: 31160782
• UniProt: Q5V8Y6