Structure of PDB 6qbh Chain B

Receptor sequence
>6qbhB (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
GVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQ
QKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYW
QVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPL
IQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGF
MGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAAR
3D structure
PDB6qbh Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.5: cathepsin D.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S43 B F126 F131 I134 Y205 D231 G233 M309 I320 F20 F25 I28 Y99 D125 G127 M203 I214 BindingDB: IC50=2.5nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6qbh, PDBe:6qbh, PDBj:6qbh
PDBsum6qbh
PubMed32003991
UniProtP07339|CATD_HUMAN Cathepsin D (Gene Name=CTSD)

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