Structure of PDB 6q3x Chain B

Receptor sequence
>6q3xB (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
QPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPM
ALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPR
WANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQ
LCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRS
LETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGAASL
REVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGR
LMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTL
LEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6q3x Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B E43 H44 D46 G183 M185 D186 Y236 G346 E38 H39 D41 G178 M180 D181 Y231 G341
BS02 HFK B R105 Y109 L135 G136 S141 S142 L145 R100 Y104 L130 G131 S136 S137 L140
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q3x, PDBe:6q3x, PDBj:6q3x
PDBsum6q3x
PubMed33724769
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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