Structure of PDB 6q04 Chain B

Receptor sequence
>6q04B (length=1159) Species: 1235996 (Human betacoronavirus 2c EMC/2012) [Search protein sequence]
TVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNI
TITYQGLFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFV
VRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNH
TLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG
NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGITQTAQGVHLFS
SRYVDLYGGNMFQFATLPVYDTIKYYSIIPHSIRSIQSDRKAWAAFYVYK
LQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFE
AKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSL
FSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQF
NYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRLLSDDRTEVPQL
VNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQL
QMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVF
QNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKET
KTHATLFGSVACEHIYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCAL
PDTPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQ
KVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLF
ASVKSSQSSPIIPGFGGDFNLTLLEPVARSAIEDLLFDKVTIADPGYMQG
YDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGV
GWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAM
QTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRL
DPPEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVK
AQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDA
ANPTNCIAPVNGYFIKTEWSYTGSSFYAPEPITSLNTKYVAPQVTYQNIS
TNLPPPLLG
3D structure
PDB6q04 Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B D510 W553 D493 W536
BS02 SIA B Q36 F39 A92 F101 I132 S133 R307 Q19 F22 A75 F84 I115 S116 R290
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046598 positive regulation of viral entry into host cell
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0061025 membrane fusion
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q04, PDBe:6q04, PDBj:6q04
PDBsum6q04
PubMed31792450
UniProtK0BRG7

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