Structure of PDB 6pyz Chain B

Receptor sequence
>6pyzB (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
GGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQIL
WELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTA
LDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYYRDNFKGEENEL
LLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRI
QAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQG
ALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAG
TGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFL
3D structure
PDB6pyz Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
ChainB
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.11: tryptophan 2,3-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H7S B Y42 Y45 Y5 Y8 MOAD: ic50=424uM
BindingDB: IC50=>50000nM
BS02 HEM B F72 H76 Y79 L132 G152 F153 F158 R159 W324 H328 M331 V332 M335 G341 G343 S345 Y350 F35 H39 Y42 L95 G115 F116 F121 R122 W283 H287 M290 V291 M294 G300 G302 S304 Y309
BS03 H7S B F72 H76 R144 A150 S151 T342 F35 H39 R107 A113 S114 T301 MOAD: ic50=424uM
BindingDB: IC50=>50000nM
BS04 ZIQ B R103 E105 W208 R211 T212 P213 I295 F304 P307 R66 E68 W167 R170 T171 P172 I254 F263 P266
Gene Ontology
Molecular Function
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0005515 protein binding
GO:0016597 amino acid binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006568 tryptophan metabolic process
GO:0006569 tryptophan catabolic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA
GO:0051289 protein homotetramerization
GO:1904842 response to nitroglycerin
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pyz, PDBe:6pyz, PDBj:6pyz
PDBsum6pyz
PubMed31682426
UniProtP48775|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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